Mig 10

Gene ID: , updated on 8-Feb

Summary

Enables SH3 domain binding activity. Involved in several processes, including egg-laying behavior; lamellipodium assembly; and nervous system development. Located in several cellular components, including growth cone membrane; neuronal cell body membrane; and presynaptic cytosol. Part of filamentous actin. Is expressed in several structures, including anal depressor muscle; intestine; neurons; rectal gland cell; and reproductive system. Orthologous to several human genes including RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1). [provided by Alliance of Genome Resources, Feb ]

Other designations

Abnormal cell migration protein 10

GeneRIFs: Gene References Into Functions

• MIG stabilizes invading cell adhesion to basement membrane and is a negative transcriptional target of EGL in C. elegans.
• MIG (lamellipodin), an effector of UNC in neurons has functions independent of UNC-6/UNC Unlike other UNC effectors, its expression is regulated by FOS-1A, a transcription factor that promotes basement membrane breaching.
• these observations suggest that MIG interacts with ABI-1 and

  Open Access

  Peer-reviewed

  • Yan Xu, 
  • Christopher C. Quinn

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  Figures

  Abstract

  Extracellular guidance cues steer axons towards their targets by eliciting morphological changes in the growth cone. A key part of this process is the asymmetric recruitment of the cytoplasmic scaffolding protein MIG (lamellipodin). MIG is thought to asymmetrically promote outgrowth by inducing actin polymerization. However, the mechanism that links MIG to actin polymerization is not known. We have identified the actin regulatory protein ABI-1 as a partner for MIG that can mediate its outgrowth-promoting activity. The SH3 domain of ABI-1 binds to MIG, and loss of function of either of these proteins causes similar axon guidance defects. Like MIG, ABI-1 functions in both the attractive UNC-6 (netrin) pathway and the repulsive SLT-1 (slit) pathway. Dosage sensitive genetic interactions indicate that MIG functions with ABI-1 and WVE-1 to mediate axon guidance. Epistasis analysis reveals that ABI-1 and WVE-1 function downstream of MIG to mediate its outgrowth-promoting activity. Moreover, experiments with cultured mammalian cells suggest that the interaction between MIG and ABI-

  List of Mikoyan and MiG aircraft

  Designation NATOYear Stage Remarks MiG-1 Production Fighter, prototypes called I MiG-3 Production Fighter and interceptor, testbed for numerous experimental variants, most notably I/MiG-9EMig-5/DIS Prototype Escort fighter; also known as the MiG-5 MiG-6 Design Reconnaissance/ground attack aircraft, remained a paper project MiG-7 Prototype MiG-3 re-engined with an AM inline engine MiG-7Reserved for an unbuilt production version of the I MiG-8 "Utka" Prototype Liaison aircraft MiG-9Fargo Production Fighter, MiG's first jet, prototype called I, testbed for variants MiGFagot Production Fighter, world's most-produced jet, prototype called I MiGFresco Production Fighter, based on the MiG MiGFarmer Production Fighter, MiG's first supersonic fighter, first mass-produced supersonic fighter, prototype called I MiGFishbed Production Fighter and interceptor, most-produced supersonic fighter, widely exported to other air forces, originally to be based on Ye-5 but instead developed from MiG variant SM, basis of many oth

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