Enterohepatisk cirkulation läkemedel

Modeling Enterohepatic Circulation

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    Absorption och eliminering av läkemedel

    Sida 1 . Copyright Erik Boberg

    4. Glukoroniden hydrolyseras av tarmfloran.
    - Antibiotikakurer

    3. Enterohepatisika kretsloppet

    - Tarm -> v. porta -> lever -> galla -> tarm: 20% av ett upptaget läkemedel kan cirkulera i detta. Då fungerar cirkulationen som en reservoar för läkemedlet.
    - Viktigt för tex morfin och etylöstradiol.
    1. Läkemedlet konjugeras med glukoronid i levern
    2. Det koncentreras i gallan
    3. Det förs till tarmen

    Levern: (biotransformation)
    1. Psystemet.
    2. Konjugering med tex gallsalter.

    Systemkretsloppet: Upptag av läkemedel (eller metaboliter) i perifera vävnader.

    Ett läkemedel vi har stoppat i oss

    1. Absorption från GI-kanal

    - Passiv transport viktigast: svaga syror/baser absorberas bättre än starka (blir oladdade i olika pH och kan då diffund

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