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Absorption och eliminering av läkemedel
Sida 1 . Copyright Erik Boberg
4. Glukoroniden hydrolyseras av tarmfloran.
- Antibiotikakurer
3. Enterohepatisika kretsloppet
- Tarm -> v. porta -> lever -> galla -> tarm: 20% av ett upptaget läkemedel kan cirkulera i detta. Då fungerar cirkulationen som en reservoar för läkemedlet.
- Viktigt för tex morfin och etylöstradiol.
1. Läkemedlet konjugeras med glukoronid i levern
2. Det koncentreras i gallan
3. Det förs till tarmen
Levern: (biotransformation)
1. Psystemet.
2. Konjugering med tex gallsalter.
Systemkretsloppet: Upptag av läkemedel (eller metaboliter) i perifera vävnader.
Ett läkemedel vi har stoppat i oss
1. Absorption från GI-kanal
- Passiv transport viktigast: svaga syror/baser absorberas bättre än starka (blir oladdade i olika pH och kan då diffund
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